EZH2 is overexpressed in breast tumors with a BRCA1-like DNA copy number profile
J Puppe, M Opdam, K Jozwiak, PC Schouten, S Rodenhuis, M Hauptmann, E Hahnen, P Mallmann, R Schmutzler, S Linn, J Jonkers · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Purpose: The polycomb group protein EZH2 is an epigenetic repressor and overexpression of EZH2 is associated with highly aggressive types of breast cancer. Human BRCA1-mutated breast tumors carry a specific DNA copy-number signature (“BRCA1-like”) which is also found in tumors with a loss of BRCA1 function by other mechanism such as BRCA1-promoter methylation. Here, we explored whether EZH2 is overexpressed in human BRCA1-like breast tumors. Patients and methods: In our study we have analyzed the abundance of EZH2 expression using immunohistochemistry in a cohort of nearly 400 patients. We classified copy-number…
