Prognostic relevance of EP3-receptor expression in sporadic breast cancer tissue
A Semmlinger, V von Schönfeldt, V Wolf, E Schmoeckel, D Mayr, S Mahner, U Jeschke, N Ditsch · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Aim: The prostaglandin EP3 receptor is one of four membrane bound receptors (EP1 – 4) identified for prostaglandin E2. Prostaglandins have a variety of biological effects; however, elevated prostaglandin synthesis has also been associated with the development of different kinds of cancer. The involvement of EP1 – 4-receptors in carcinogenesis has been suggested. Furthermore, EP3 is known to regulate the uPA/PAI-1 pathway. This analysis evaluates the expression of EP3-receptor on breast cancer tissue and its correlation to recurrence and survival. Material and methods: A total of 320 sporadic breast cancer tissue…
