Placental alpha-microglobulin-1 in cervico-vaginal fluid predicts preterm birth in women with preterm labor and intact membranes

Introduction: Preterm birth is a major cause of neonatal morbidity and mortality in developed countries. The placental alpha-microglobulin-1 (PAMG-1) is a protein that can be found in high concentrations in the amniotic fluid and in lower concentrations in the vaginal secretion in patients with signs of preterm labor without rupture of membranes. We aimed to evaluate PAMG-1 diagnostic kit in the prediction of preterm birth. Material and methods: We included 119 patients (between 24 0/7 and 36 6/7 gestational weeks) in this prospective observational trial. We included patients with symptoms of preterm labor and g…