Expression and impact of TFF3 in epithelial ovarian cancer
F Hoellen, A Rody, A Kostara, T Karn, U Holtrich, A El-Balat, M Otto, L Hanker · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Aim: The role of trefoil factor 3 (intestinal) (TFF3) has been analyzed in a multitude of cancers, e.g. breast cancer and gastrointestinal cancers, and has been associated with poor prognosis. Still, the role of TFF3 in ovarian cancers is not clear. Materials and methods: Expression analysis of TFF3 in n = 91 ovarian cancer patients was performed by immunohistochemistry of primary paraffin embedded tumor samples. Results were scored according to staining intensity and percentage of positive tumor cells resulting in an immune-reactive score 0 – 12 (IRS). These results were correlated to clinical and pathological…