Validity parameters of the HPV detection tests HC2 and APTIMA with and without cytology smears after surgical treatment of high grade cervical intraepithelial neoplasia lesions

Objectives: After surgical management of cervical intraepithelial neoplasia (CIN) lesions, HPV DNA or mRNA tests may provide better validity parameters than cytology smears alone. Methods: 266 women with a suspicious colposcopy finding during follow-up examinations after surgical treatment of CIN lesions were included into this study. Routine cytology and HPV genotyping smears were obtained. Digene Hybrid Capture 2 (HC2) HR-HPV DNA, APTIMA HPV assays and cervical biopsies of suspect areas were performed. Validity parameters including positive and negative predictive values (PPV, NPV) were calculated using the ce…