Enhanced radiation efficiency by gold nanoparticles after proton beam irradiation in medulloblastoma cell lines

Introduction: In pediatric oncology, one quarter of patients is diagnosed with a tumor of the CNS. Although outcome did improve significantly during the last decade, prognosis of malignant CNS-tumors in childhood is still lagging behind and needs further improvement. Especially for relapse patients, prognosis is worse and curative therapy approaches are missed. Besides radical resection and chemotherapy, radiotherapy is standard of care. However, secondary malignancy after treatment of CNS-tumors in childhood occurs in 5.5% of cases, thus accounting for 19% of all secondary cancers in childhood tumors. Although…