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Pamidronate and calcitonin as therapy of acute cancer-related hypercalcemia in children

I. Schmid, D. Stachel, C. Schön, M. Bauer, R. J. Haas · Klinische Pädiatrie · 2001 · Heft 01 · S. 30-34

Dokument
847909
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Jahr
2001
Publikation
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
I. Schmid, D. Stachel, C. Schön, M. Bauer, R. J. Haas
Ausgabe
Heft 01 / 2001
Jahrgang 213
Seiten
30-34
Erschienen: 2001-01-01 00:00:00
ISSN
0300-8630
DOI
10.1055/s-2001-11271

Zusammenfassung

Abstract. Severe symptomatic hypercalcemia is a rare event in children with malignancies. Up to now there is limited experience treating childhood hypercalcemia with bisphosphonates in addition to calcitonin. We report a 5-year-old boy with acute lymphoblastic lymphoma who presented with malignant hypercalcemia at diagnosis. The maximal serum calcium concentration was 15.2 mg/dl (3.81 mmol/l). Conventional therapy with forced diuresis and furosemide failed. Calcitonin (10 IU/kg/24 h i.v. for 2 days) and pamidronate (1 mg/kg over 2 hours i.v.) were used successfully without adverse effect lowering the serum calci…

Schlagworte

Cancer-related hypercalcemia childhood pamidronate calcitonin Hyperkalzämie durch maligne Erkrankun-gen Kinder Pamidronat Klinische Pädiatrie