CareLit Fachartikel
Chimärismusanalyse nach Stammzelltransplantation mit hochsensitiven Methoden
Andreas Heinold, Falko M. Heinemann, Markus Ditschkowski · Transfusionsmedizin · 2022 · Heft 04 · S. 227-232
Dokument
848834
CareLit-ID
Jahr
2022
Publikation
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Metadaten
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Zusammenfassung
AbstractChimerism analysis is important for monitoring engraftment and indicating the recurrence of malignant cells after allogeneic hematopoietic stem cell transplantation. Highly sensitive methods with a detection limit of recipient cells (equivalents) below 0,1%, e. g. quantitative PCR, droplet digital PCR and, most recently, Next-Generation Sequencing, can predict a relapse up to 120 days earlier when compared to less sensitive methods. This review highlights the importance of assessing the dynamics of chimerism in the low percentage range (below 1%) for the prediction of a relapse. Moreover, the authors pro…
Schlagworte
Chimärismus
Stammzelltransplantation
quantitative PCR
droplet digital PCR
Next-Generation Sequencing
Chimerism
stem cell transplantation
Transfusionsmedizin
