CareLit Fachartikel
IGF-I receptor-dependent mitogenic effect of platelet- derived growth factor in rat liver myofibroblasts
R Novosyadlyy, G Ramadori, JG Scharf · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Dokument
850206
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Jahr
2004
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Zusammenfassung
Background and aims: Insulin-like growth factor-I (IGF-I) is a potent mitogen for rat liver MF. Both IGF-I and its specific receptor (IGF-IR) are constitutively expressed in MF, possibly contributing to liver fibrogenesis via an autocrine loop. Since IGF-I is known as a progression factor for the growth-promoting effects of platelet-derived growth factor (PDGF) in many cell types, the aim of this work was to study the effect of PDGF on MF proliferation and to examine possible cross talk between PDGF and the IGF system components in MF. Methods: Cultures of MF from passages 1 to 4 were studied. DNA synthesis was…
Schlagworte
IGF-I
IGF-I receptor
PDGF
liver
myofibroblasts
Zeitschrift für Gastroenterologie
