Binding of Hepatitis C Virus Envelope to Target Cells Induces a Cascade of Cell Signals Important for Antiviral Immune Responses and Lipid Metabolism
X Fang, J Wilpert, H Barth, B Gissler, C Kreutz, J Donauer, F von Weizsäcker, HE Blum, TF Baumert · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Bibliografische Angaben
Zusammenfassung
Background. Hepatitis C virus (HCV) envelope glycoproteins interact with several cell surface proteins including CD81, scavenger receptor B1 and heparan sulfate proteoglycans. The implication of this interaction for target cell function is unknown. Binding of HIV envelope proteins to cell surface receptors has been shown to result in a cascade of signals modulating cellular gene expression favoring viral replication (Cicala et al. 2002; Proc. Natl. Acad. Sci. 99: 9380–9385). In this study we aimed to characterize the cellular response following binding of HCV envelope glycoproteins to target cells. Experimental…
