Characterization of the biological aktivities of uridine diphosphate in human dendritic cells: Influence on chemotaxis and CXCL8 release

Uridine nucleotides are endogenous nucleotides which are released into the extracellular space from mechanical stressed endothelial and epithelial cells as well as lipopolysaccharide (lps)-stimulated monocytes. Here, we studied the biological activity of the selective purinoreceptor P2Y6 (P2YR6) agonist uridine diphosphate (UDP) as well as the P2YR2- and P2YR4-activating uridine triphosphate (UTP) on human dendritic cells (DC). Immature DC have the ability to migrate from blood to peripheral target sites where they sense for dangerous signals and capture potential antigens. Mature DC induce innate immune respons…