Therapy resistant ulcerative colitis associated with high MDR1 function

Background: Current drugs to treat inflammatory bowel disease (IBD) incl. corticosteroids, azathioprine, cyclosporine are all substrates of ABC-MDR transporters. Testing MDR-transporter function to establish personalized treatment strategies is an increasingly accepted issue by various methods including DNA chip arrays and Flow Cytometry. In addition, it is uncertain, whether or not peripheral blood mononuclear cells could be used for screening purposes. Our patient: a 70 years old female patient was referred to our unit with therapy resistant ulcerative colitis (UC) involving the sigmoid colon and the rectum. S…