How can we decrease the risk of colorectal carcinoma in the general population with pedigree analyses

Morbidity and mortality of colorectal cancer (CRC) is extremely high in Hungary, ranked on the second place in both gender. General population screening for CRC is not resolved yet in Hungary, therefore special attention should be attracted to the two main groups of high risk carriers: on the one hand sporadic CRC cases with familiar accummulation with a relative risk (RR) of 1.5–2.25, and the group of genetically determined cancer syndromes with an RR of 4.25–50. Family report: the pitfalls of clinical evaluation regarding different relative risks affecting members of the same family will be demonstrated in a d…