First observations with dextran sulphate induced intestinal inflammation in the histamin deficient, histidine decarboxylase knockout mice

Objectives: The aim of the study was to elucidate whether the lack of histamine has an effect on the development of colitis. Methods: Histamine deficient, histidine decarboxylase (HDC) knockout Balb/c mice and control animals with the same background but with intact HDC were studied. The inflammation was induced by the administration of 2% dextran sodium sulphate in the drinking water. The mice was sacrified after five days in order to examine the disease activity by clinical, histological and immunohistological parameters. The bacterial components of stool were examined by bacteriological methods. Results: The…