The M6P/IGF2-receptor gene shows allelic loss but is not mutated in ependymomas

Ependymal tumors are heterogeneous with regard to morphology, localization, age at manifestation, and prognosis. Spinal tumor location, which predominantly occurs in adults, is associated with a better prognosis than intracranial ependymomas, which represent the majority of childhood ependymomas. While spinal ependymomas are associated with allelic losses on chromosome 22q and mutations in the NF2 tumor suppressor gene, losses of 6q have frequently been observed in pediatric ependymomas. The mannose 6-phosphate/insulin-like growth factor 2 receptor gene (M6P/IGF2R) gene is located at 6q26. It encodes a multifunc…