Human mast cell mediators excite neurones in murine and human enteric nervous system

Neuroimmune interactions are an integral part of gut pyhsiology and involved in the pathogenesis of inflammatory as well as functional bowel disorders. Mast cells and their mediators are pivotal to communicate information from the innate enteric immune system to the enteric nervous system. So far it is not known whether a mediator cocktail released from activated human mast cells affect neural activity and whether mast cell mediators have effects on human enteric nerves. We used the Multi-Site Optical Recording Technique to image single cell activity in guinea-pig and human enteric nervous system after applicati…