Reductions in Serum Hepatitis B Surface Antigen (HBsAg) Occur in Parallel with Reductions in Intrahepatic HBV Covalently Closed Circular (ccc) DNA in Chronic Hepatitis B (CH-B) Pa…
K Wursthorn, P Buggisch, F Metzler, B Werle, F Zoulim, SA Locarnini, W Delaney, S Xiong, H Greten, J Petersen · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: We previously demonstrated that 48 weeks of ADV therapy reduced intrahepatic HBV cccDNA by a median of 86% (p=0.002 vs. placebo) in CH-B patients and was correlated with significant reductions in serum and intracellular HBV DNA (HEPATOLOGY 2002;36: 296A). Since HBV cccDNA is the transcriptional template for HBsAg, we investigated whether reductions in cccDNA translated into significant reductions in serum HBsAg titer. Aims: To determine if 48 weeks of ADV therapy reduced serum HBsAg titer in CH-B patients. To determine if changes in HBsAg titer correlate with changes in intrahepatic cccDNA levels.…
