The Executive Motor System works Harder when Moving the Non-Preferred Hand

Purpose: The aim of the present study was to investigate whether human hand preference has a functional correlate in movement-related neuronal activity. Methods: 12 right-handed and 13 left-handed volunteers performed visually cued choice reaction time tasks during event-related 3 Tesla fMRI. The experimental design comprised five conditions, differing in the amount of choice given by spatial cues. Responses were made with the left or right index or middle finger. Subjects were required to choose and execute brisk flexion movements with only one finger in response to the spatial cue. Data were analyzed with SPM2…