CareLit Fachartikel

Pharmacological Consolidation of Motor Cortical Neuroplasticity in Humans

MA Nitsche, J Grundey, W Jaussi, D Liebetanz, N Lang, F Tergau, W Paulus · Klinische Neurophysiologie · 2004 · Heft 08

Dokument
851599
CareLit-ID
Jahr
2004
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
MA Nitsche, J Grundey, W Jaussi, D Liebetanz, N Lang, F Tergau, W Paulus
Ausgabe
Heft 08 / 2004
Seiten
–
Erschienen: 2004-08-25 00:00:00
ISSN
1434-0275
DOI
10.1055/s-2004-832111

Zusammenfassung

Introduction: Amphetamine, a catecholaminergic re-uptake blocker, and D-cycloserine, a partial NMDA receptor-agonist, are able to improve neuroplastic mechanisms in humans. However, so far not much is known about the underlying physiological mechanisms. Here we study the impact of amphetamine and D-cycloserine on NMDA receptor-dependent excitability modifications in the human motor cortex elicited by weak transcranial direct-current stimulation (tDCS). Methods: tDCS protocols which elicit long-lasting motor cortical excitability modifications were applied under premedication with 20mg amfetaminil (AMP), 100mg D-…

Schlagworte

Klinische Neurophysiologie