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Mechanisms of homocysteine (neuro)toxicity: a novel point of view

U Wüllner, H Lutz, E Jarre, S Vielhaber, T Klockgether, W Kunz, M Linnebank · Aktuelle Neurologie · 2004 · Heft 09

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851685
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Jahr
2004
Publikation
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
U Wüllner, H Lutz, E Jarre, S Vielhaber, T Klockgether, W Kunz, M Linnebank
Ausgabe
Heft 09 / 2004
Seiten
–
Erschienen: 2004-09-07 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2004-833381

Zusammenfassung

Hyperhomocysteinemia has been associated with vascular disease and neurodegeneration. We investigated the effects of homocysteine (Hcy) on mitochrondrial electron transport chain activity in dopaminergic rat pheochromocytoma (PC12) cells. Hcy dose-dependently induced apoptotic cell death. However, with LD50 dosage, no significant induction of reactive oxygen species occurred and Complex I activity was only marginally reduced. Instead, activity of the cytochrome c oxidase (COX) was dramatically decreased (7.7%±2.9% of control, mean±SD, p

Schlagworte

Aktuelle Neurologie