CareLit Fachartikel
Interferon-gamma acts proapoptotic on Hepatic Stellate Cells (HSC) and abrogates the antiapoptotic Effect of Interferon-alpha by an HSP70 dependant Pathway
B Saile, C Eisenbach, J Dudas, G Ramadori · Zeitschrift für Gastroenterologie · 2005 · Heft 01
Dokument
852060
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Jahr
2005
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Zusammenfassung
The activated hepatic stellate cell (HSC) is an important fibrogenic cell type of the liver. Interferon-α (IFN-α) has recently been shown to elicit an antiapoptotic effect on activated HSC by a JAK–2-dependent inhibition of caspase–8 activation. As JAK–2 has so far been shown to be a member of the IFN-γ signal transduction pathway we studied the effect of IFN-γ on apoptosis as well as on its signaling in primary cultured rat HSC. IFN-γ elicted a proapoptotic effect in activated HSC. The combination of both, IFN-γ and IFN-α, however, completely cancelled each other's effect. No effect of the two cytokines on majo…
Schlagworte
HSP70
apoptosis
hepatic stellate cells
Caspase 8
Cytokines
After
Zeitschrift für Gastroenterologie
