CareLit Fachartikel

New Combinatory Treatment on a Rat HCC Model

M Ganslmayer, A Zimmermann, S Zopf, M Ocker, D Schuppan, EG Hahn, C Herold · Zeitschrift für Gastroenterologie · 2005 · Heft 01

Dokument
852065
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Jahr
2005
Publikation
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Metadaten
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Ganslmayer, A Zimmermann, S Zopf, M Ocker, D Schuppan, EG Hahn, C Herold
Ausgabe
Heft 01 / 2005
Seiten
–
Erschienen: 2005-01-14 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2005-861631

Zusammenfassung

Aim: Hepatocellular carcinoma (HCC) is refractory to conventional chemotherapy. Especially histonedeacetylase (HDAC) inhibitors enhanced the effectivity of combination partners significantly. Therefore we evaluated a VEGF receptor antagonist (V-blocker), a HDAC inhibitor (Trichostatin A, TSA) and/or Tamoxifen (TAM) in a syngenic Morris hepatoma model. Methods: 10×106 Morris-hepatoma cells (MH777A) were implanted into the liver of adult immunocompetent Buffalo rats (8 animals per group). The rats received V-Blocker (50mg/kg BW every second day), the HDAC inhibitor Trichostatin A (TSA 100µg/kg BW daily) or TAM (3/…

Schlagworte

Tumor Apoptosis After Zeitschrift für Gastroenterologie