High expression of claudin-4 in human biliary cancers

Introduction and Aim: Cell adhesion molecules play an important role in carcinogenesis, especially claudins, being part of tight junctions. The importance of certain claudins in development of several tumors has been shown, and some of them have even been suggested as a future therapeutic target. For this reason, the aim of our study was to analyse the expression of claudins in biliary cancers (BCs). Patients and Methods: A tissue microarray comprising 24 biliary cancers, arising from different localisations (gallbladder, common bile duct, intrahepatic bile ducts) was constructed to investigate claudin-1, -2, -3…