Substance P inhibits pancreatic ductal HCO3-secretion via activation of protein kinase C in guinea pig
B Ozsvari, Z Rakonczay, L Tiszlavicz, T Takacs, G Papp, J Lonovics, A Toth, G Racz, G Varga, M Gray, B Argent, P Hegyi · Zeitschrift für Gastroenterologie · 2005 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background. The inhibitory control of pancreatic ductal HCO3- secretion may be physiologically important in terms of limiting the hydrostatic pressure developed within the ducts and in terms of switching off pancreatic secretion after a meal. Substance P (SP) inhibits secretin-stimulated HCO3- secretion by modulating a Cl–dependent HCO3-efflux step at the apical membrane of the duct cell (Hegyi et al. Am J Physiol Cell Physiol 285: C268-C276, 2003). In the present study we have sought to localise SP in the guinea-pig pancreas and to identify the intracellular signalling pathway utilised by SP. Methods. Small int…
