ACTIVATION OF TUMOR SPECIFIC T LYMPHOCYTES AFTER RADIO-FREQUENCY ABLATION IN PATIENTS WITH HEPATOCELLULAR CARCINOMA AND COLORECTAL LIVER METASTASES
TTill Wissniowski, D Schuppan, M Ocker, D Strobel, T Bernatik, M Frieser, EG Hahn, J Hänsler · Ultraschall in der Medizin - European Journal of Ultrasound · 2005 · Heft 09
Bibliografische Angaben
Zusammenfassung
Purpose: Radio-frequency ablation (RFA) is widely used as a treatment of inoperable tumor lesions in the liver. Thermal necrosis and the perilesional inflammatory infiltrate induced by RFA may enhance antitumoral immunity. To assess if a specific T cell response can be induced in patients with malignant liver tumors treated with RFA. Methods and Materials: 6 Patients with liver metastases of colorectal cancer and 6 with hepatocellular carcinoma (HCC) underwent RFA. Blood was sampled before, 4 and 8 weeks after RFA. Test antigens were autologous liver and tumor lysate obtained from each patient by biopsy. T cell…
