MTX-induced white matter changes are associated with polymorphisms of methionine-metabolism
M Linnebank, H Pels, N Kleczar, S Farmand, K Fließbach, H Urbach, K Orlopp, I.G.H Schmidt-Wolf, T Klockgether, U Schlegel · Aktuelle Neurologie · 2005 · Heft 10
Bibliografische Angaben
Zusammenfassung
Objective: CNS demyelination presenting with CNS white matter changes (WMC) in MRI is a typical side-effect of high-dose methotrexate (MTX) chemotherapy. We speculated that the underlying mechanism may be an inhibition of methionine synthesis due to a MTX-induced lack of 5,10-methylenetetrahydrofolate. We studied whether development of WMC in high-dose MTX-treated 42 patients with primary CNS lymphoma (PCNSL) is associated with functional polymorphisms which might modify the effect of MTX on methionine synthesis: methionine synthase (MTR) c.2756A>G (D919G), 5,10-methylenetetrahydrofolate reductase (MTHFR) c.677C…
