Modulation of adult stem cell fate by inhibitors of histone deacetylases

Epigenetic modulation of the chromatin structure influences cellular differentiation. Inhibitors of histone deacetylases (HDAC) are challenging compounds and increase chromatin hyperacetylation, which is associated with transcriptional activation. Among the panel of upregulated genes are neuronal transcription factors, which opens the intriguing possibility to target the fate of adult stem cell differentiation by HDAC inhibitors. Here, we tested whether HDAC inhibitors influence the differentiation pattern of adult stem cells obtained from rat subventricular zone. Valproic acid, sodium butyrate and MS-275, compo…