CareLit Fachartikel

Interferon beta-1a increases leukocyte TNF-R1 and decreases TNF-R2 gene expression in human MS therapy responders, thus TNF-a signalling via TNF-R1 might be beneficial, via TNF-R2…

R Reuß, S Pohle, K Retzlaff, S Mannes-Keil, C Burger, S Vogel, M Kaps, P Oschmann · Aktuelle Neurologie · 2005 · Heft 10

Dokument
853928
CareLit-ID
Jahr
2005
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
R Reuß, S Pohle, K Retzlaff, S Mannes-Keil, C Burger, S Vogel, M Kaps, P Oschmann
Ausgabe
Heft 10 / 2005
Seiten
–
Erschienen: 2005-10-26 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2005-919401

Zusammenfassung

Introduction: Tissue specifically expressed tumor necrosis factor receptors 1 and 2 (TNF-R1/2) transduce apoptosis or inflammation (Hsu, 1996). In a case, R1 mediates apoptosis in contrast to R2 (Shimizu et al., 2005). Neutralizing TNF-a, e.g. by lenercept, lead to clinical or subclinical relapses. Objective: To investigate the influence of IFN beta-1a on leukocyte TNF-R1 and -R2 gene expression in RR-MS patients. Methods: 53 RR-MS patients were observed (open parallel-group study, 1 year). Every 2nd day, 26 therapy starters were treated with 22 ug IFN beta-1a (T). The MS control group (C) comprised 27 patients,…

Schlagworte

Aktuelle Neurologie