Hepatitis C Virus Structural Proteins and Activation of Toll-like Receptor 2 and 4
M Hoffmann, P Henneke, H Barth, B Gissler, G Paranhos-Baccalà, DT Golenbock, HE Blum, TF Baumert, TF Baumert, H Barth · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background and aim: Hepatitis C virus (HCV) is a major cause of chronic hepatitis worldwide. Toll-like receptors (TLRs) are pathogen recognition molecules that activate the innate immune system. Recognition of pathogen-associated molecular patterns (PAMPs) by TLRs induces the activation of genes important for an effective host defence. Previous studies show that TLRs are involved in the human host defence against viruses such as HSV, CMV, RSV and measles virus. In this study we aimed to elucidate whether TLR2 and 4 interact with HCV structural proteins. Methods: TLR2 and 4 activation was assessed in stably trans…
