A monoclonal antibody against murine PlGF blocks primary tumor growth in syngeneic mouse tumor models

Gene targeting studies in mice have elucidated a functional role of placental growth factor PlGF, a homologue of VEGF, in pathological angiogenesis. Loss of PlGF, while not causing any vascular defects during embryonic development, reproduction or normal adult life, impaired angiogenesis in pathological conditions, such as cancer. We generated a neutralizing anti- mPlGF monoclonal antibody which inhibits PlGF binding to its receptor Flt1. Here we report the effect of this anti-mPlGF mAb on tumor angiogenesis and growth in syngeneic, subcutaneous B16 melanoma, CT26 colon and orthotopic Panc02 pancreatic tumor mod…