Combined analysis to evaluate two different modes of intake of a new 2 litre PEG+E gut cleansing solution for the efficacy, acceptability and safety

Aim: To investigate if different schedules for oral intake of a new 2-litre PEG+E plus ascorbate-containing gut cleansing solution (2L PEG+E) have an effect on the bowel cleansing quality. Methods: Four controlled clinical studies assed in 413 patients the use of the new 2L PEG+E solution using different schedules of intake. All studies assessed the efficacy, acceptability and safety of Mode 1 („split intake“) with 1L in the evening followed by 1L on the morning of the colonoscopy versus Mode 2 („single intake“) with 2L in the evening before the colonoscopy (control: established comparators). Random allocation w…