Genotyping of Caucasian individuals in the dihydropyrimidine dehydrogenase gene
E Gross, K Seck, S Riemer, R Kates, T Ullrich, V Lutz, N Harbeck, M Schmitt, R Diasio, M Kiechle · Zentralblatt für Gynäkologie · 2005 · Heft 10
Bibliografische Angaben
Zusammenfassung
Germline mutations in the dihydropyrimidine dehydrogenase gene (DPYD) have been associated with inactivation of the enzyme dihydropyrimidine dehydrogenase (DPD), which is involved in the catabolism of the anticancer drug 5-fluorouracil (5-FU). Loss of DPD appears to be involved in severe drug-adverse effects following administration of 5-FU in cancer patients. We performed a population study to evaluate the frequency of sequence variations in the DPYD gene in a Caucasian population. Therefore, a cohort of n=157 individuals was analyzed by denaturing HPLC and the genotypes were correlated with functional data. 22…
