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Pro-hepcidin levels are decreased in advanced hepatitis C liver disease

T Göbel, A Erhardt, K Hauck, A Janetzko, A Donner, T Heintges, D Häussinger · Zeitschrift für Gastroenterologie · 2006 · Heft 01

Dokument
854317
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
T Göbel, A Erhardt, K Hauck, A Janetzko, A Donner, T Heintges, D Häussinger
Ausgabe
Heft 01 / 2006
Seiten
–
Erschienen: 2006-01-16 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2006-931681

Zusammenfassung

AIM: Iron homoestasis is impaired in chronic hepatitis C. The hepatic peptide hormone hepcidin is thought to play an important role in both, iron metabolism and inflammation. Therefore, pro-hepcidin levels were determined in patients with chronic hepatitis C. Methods: Pro-hepcidin levels were measured by ELISA in the serum of 175 patients with chronic HCV infection and 66 healthy controls. Additionally, serum iron parameters and HFE-mutations were determined. Results: Pro-hepcidin levels were significantly lower in patients with chronic hepatitis C compared to healthy controls (144±13 ng/ml vs. 402±51 ng/ml; p

Schlagworte

virus – HFE – hepcidin – iron – hepatitis C Zeitschrift für Gastroenterologie