PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis
M Mühlbauer, M Fleck, T Weiss, M Froh, C Schütz, C Blank, J Schölmerich, C Hellerbrand · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Bibliografische Angaben
Zusammenfassung
B7-H1 (PD-L1) is a B7-family member that binds to programmed death–1 (PD–1). Recently, deficiency of PD-L1 has been demonstrated to result in accelerated hepatocyte damage in experimental autoimmune hepatitis, and PD-L1 was suggested to play a critical role in regulating T-cell homeostasis. Absence of PD–1 enhanced proliferation of T cells in adenovirus-infected livers and resulted in a rapid clearance of the virus. The aim of this study was to analyze the expression and function of PD-L1 in hepatocytes. Methods and Results: Constitutive expression of PD-L1 at low levels was detected in primary human hepatocytes…
