Impairment of cognitive transcallosal functions in mild relapsing- remitting multiple sclerosis

Objective: To study the transcallosal dysfunction in terms of cognitive impairment, disturbance of transcallosal motor inhibition (TCI) and morphological involvement in patients with mild multiple sclerosis (MS). Methods: 35 MS patients with mean EDSS of 2,5 and 30 control subjects were submitted to a neuropsychological test battery testing including attention, language and memory as well as tasks that predomaninatly assess interhemispheric functions. The transcallosal inhibition was assessed by transcortical magnetic stimulation and lesion loading in MS patients was assessed by T2 weighted and FLAIR magnet reso…