Task-related high-frequency synchrony in the subthalamic nucleus (STN) during precision grip

The STN is a pivotal element in the neuronal network exhibiting abnormal firing patterns in Parkinson's disease (PD). The STN has become the most effective target of therapeutic deep brain stimulation (DBS) in PD. In the present study, neuronal synchrony was studied by EEG coherence analysis in 6 PD patients during a precision grip task. The goal of the experiments was to assess if there are any task-related modulations of neuronal synchrony inside the STN and/or between STN, motor cortex and muscle. EEG was recorded from 12 scalp electrodes (FC1, C1, CP1, FC3, C3, CP3, FC2, C2, CP2, FC4, C4, CP4), and 4 subcort…