In vitro determination of the optimal aerosol particle size for inhalation therapy in preterm infants

Background: As inhaled therapy in preterm infants with IRDS (Infant Respiratory Distress Syndrome) or CLD (Chronic Lung Disease) is difficult, the current therapy consists of Surfactant instilled through a tracheal tube or systemic steroids applied orally or intravenously. Current commercially available inhalation devices are not suitable for this age group. New mesh devices able to produce very small particles may allow age specific aerosol therapy and may be applicable even in preterm infants. Objective: This in vitro study assesses the particle size of nebulised aerosols and the distribution in the upper airw…