E266K CARD4/NOD1 and toll-like receptor 4 gene polymorphisms in Helicobacter pylori-infected patients with duodenal ulcer or gastritis
A Tiszai, Z F. Kiss, Z Gyulai, P Hofner, L Tiszlavicz, Z Lénárt, Y Mándy, J Lonovics · Zeitschrift für Gastroenterologie · 2006 · Heft 06
Bibliografische Angaben
Zusammenfassung
Background: Helicobacter pylori (HP) can be recognized in epithelial cells by the intracellular pathogen receptor NOD1 or extracellular LPS detecting toll-like receptor 4 (TLR4). The aim was to evaluate the frequency of NOD1 and TLR4 gene polymorphism in HP-infected patients with duodenal ulcer (DU) and gastritis. Patients. 131 HP-positive patients with dyspeptic symptoms were examined by gastroduodenoscopy. HP positivity was detected by 13C-UBT and histopathology. DU was found in 58 and gastritis in 73 patients. Methods. E266K CARD4/NOD1 (G to A) was determined by RFLP, and the TLR4 (ASP/299/Gly and Thr/399/Ile…
