Effects of weight loss combined with physical activity on intramyocellular lipids

High intramyocellular lipids (IMCL) combined with low physical fitness are associated with insulin resistance. Lifestyle intervention with weight loss leads to a reduction of IMCL and to a concomitant increase in insulin sensitivity (IS). On the other hand, it was surprisingly reported that a combination of weight loss and exercise does not lead to a reduction in IMCL. The aim of the present study was to which characterize factors determine the individual response of IMCL during a combined weight loss and exercise program. 80 healthy, non-diabetic, sedentary subjects (34 males and 46 females, age 44±11 years) pa…