Alternate site (like) phenomenon: Rapid changes from hypoglycemic to hyperglycemic glucose levels in a clinical-experimental study in patients with type 1 diabetes

Intoduction: Monitoring of glucose changes by SMBG and by continuous glucose monitoring (CGM) systems is prone to certain delays during rapid changes in glycemia if the blood sample is collected at non-glabrous skin or in deeper layers of the skin. Methods: Aim of this study was to evaluate the magnitude of such delays in a glucose-clamp study and during a standardized meal in 15 patients with type 1 diabetes (6 female/9 male; age 31±8 years (mean±SD); BMI 26,5±2,9kg/m2; HbA1c 7,1±0,9%; duration of diabetes 4±3 years). Venous blood glucose levels were measured continuously by means of the Biostator and in sc int…