A randomized controlled trial on the effects of adding vitamin B 12 and folate
N Haiden, K Klebermass, F Cardona, J Schwindt, A Berger, C Kohlhauser-Vollmuth, B Jilma, A Pollak · Zeitschrift für Geburtshilfe und Neonatologie · 2006 · Heft 11
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Zusammenfassung
Objective: Premature infants, especially those with a birth weight less than 1500g, often suffer from anemia of prematurity and associated problems. Erythropoietin (Epo) therapy is a safe and effective way to prevent and treat anemia of prematurity. We hypothesized that combined administration of vitamin B12 and folate with Epo and iron may enhance Epo-induced erythropoiesis. Design: In a randomized controlled trial, 64 premature infants (birth weight 801–1300g) receiving Epo and iron supplementation were randomized to either vitamin B12 (3µg/kg/d) and folate (100µg/kg/d) (treatment), or a lower dose of folate (…
