Mechanisms by which the amylin analog pramlintide reduces postprandial glucose (PPG) excursions in humans: Important role for splanchnic glucose sequestration
HJ Wörle, M Albrecht, R Linke, M Nicolaus, M Storr, J Limmer, S Zschau, C Neumann, B Göke, J Schirra · Zeitschrift für Gastroenterologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Pramlintide helps reduce PPG excursions by slowing gastric emptying (GE). PPG increases occur due to increases in the rate of glucose appearance. The latter is the sum of endogenous glucose production and the appearance of ingested glucose not been sequestered by the liver. Thus PPG reduction could result from greater suppression of endogenous glucose production or greater meal splanchnic sequestration. Methods: Nine healthy subjects were studied (4M, 5F, 41 3 y, BW 84 3kg, BMI 27.8 1.1kg/m2). After 3-h primed continuous 13-C glucose infusion, 30µg pramlintide or placebo (PBO) were injected sc and subjects ate a…
