Reliability of histological diagnosis of low grade dysplasia in Barrett's esophagus. A comparison between specialized and general pathologists

Aims: It is well known that low-grade intraepithelial neoplasia (LGIN) in Barrett's esophagus (BE) might progress to high-grade intraepithelial neoplasia (HGIN) or carcinoma (BC) with a likelihood of 10–28%. Therefore, regular follow-up endoscopies with biopsies are recommended. Since accurate diagnosis of LGIN is difficult, general pathologists (GP) are frequently uncertain in the diagnosis of LGIN and its follow-up risks. In this study, we analyse the divergence between the diagnoses of GP and specialized GI pathologists (GIP). Methods: 50 patients (pts) with previous diagnosis of LGIN in BE, made by a GP, wer…