HBsAg seroconversion in a HIV co-infected patient during combination therapy with adefovir dipivoxil and pegylated interferon alfa 2b followed by HBsAg seroreversion and viral reo…

Co-infection of HBV and HIV is common due to overlapping routes of transmission accompanied by an increased risk for liver-related mortality. We report the case of a chronically infected HBeAg positive patient, co-infected with HIV (CD4 >500/ul), with histological evidence of advanced liver disease. The patient developed anti-HBs seroconversion, strong reduction of intrahepatic cccDNA and remarkable improvement of liver histology after 24 weeks of HBV targeted combination therapy with adefovir dipivoxil and pegylated interferon alfa2b followed by another 12 weeks of adefovir dipivoxil monotherapy. Antiviral ther…