The involvement of the GGA protein family in BACE transport and APP processing in Alzheimer's disease

Introduction: Abeta plaques are one of the pathological hallmarks in Alzheimer's disease (AD). Abeta generation is caused by sequential cleavage of the amyloid precursor protein (APP). Beta-site of APP-cleaving enzyme (BACE) is known to cleave APP followed by Gamma-secretase. The resulting Abeta accumulates in extracellular senile plaques and is associated with further neuron degeneration. APP and BACE traffic together. GGA1, a member of the Golgi-localized gamma-ear-containing ARF binding (GGA) protein family interacts with BACE phosphorylation dependent via its VHS domain in the Golgi and influences its subcel…