CareLit Fachartikel

Expression of HGF-a, c-met and E-cadherin in carcinoma of the cervix uteri and correlation to different patterns of invasion

J Einenkel, UD Braumann, N Pannicke, M Höckel, LC Horn · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
855366
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
J Einenkel, UD Braumann, N Pannicke, M Höckel, LC Horn
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1089011

Zusammenfassung

Objectives. Different patterns of invasion (PI) which represent different grades of tumor cell dissociation at the front of invasion have been shown to be of prognostic impact in carcinoma of the cervix uteri. But, limited knowledge exist about molecular data influencing the PI. Methods. In 76 patients with cervical carcinoma FIGO IB-II the front of invasion was examined regarding different types of PI (closed, finger-like and spray-like) and its correlation to immunohistochemical expression of HGF-a, c-met and e-cadherin. Results. There were overexpression of HGF-a and c-met in 57% and 73% of all cases, whereas…

Schlagworte

c-met cervical cancer e-cadherin hgf invasion pattern Geburtshilfe und Frauenheilkunde