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The NOD2 variants rs2066843 and rs2076756 are novel independent Crohn's disease susceptibility gene variants associated with severe penetrating disease phenotype resulting in freq…

J Seiderer, J Glas, J Diegelmann, G Pasciuto, C Tillack, S Pfennig, M Jürgens, A Konrad, HP Török, U Schiemann, T Griga, W Klein, JT Epplen, T Mussack, P Lohse, B Göke, T Ochsenkühn, M Folwaczny, B Müller-Myhsok, S Brand · Zeitschrift für Gastroenterologie · 2008 · Heft 09

Dokument
855405
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Jahr
2008
Publikation
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
J Seiderer, J Glas, J Diegelmann, G Pasciuto, C Tillack, S Pfennig, M Jürgens, A Konrad, HP Török, U Schiemann, T Griga, W Klein, JT Epplen, T Mussack, P Lohse, B Göke, T Ochsenkühn, M Folwaczny, B Müller-Myhsok, S Brand
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-17 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0028-1089401

Zusammenfassung

Background and Aims: A number of studies indicates a strong association of the three common NOD2/CARD15 variants p.R702W, p.G908R, and p.Leu1007fsX1008 with Crohn's disease (CD) while the role of other NOD2 variants has not been investigated in detail. We therefore aimed to test the association and phenotypic consequences of two recently identified NOD2 variants (SNPs rs2066843 and rs2076756) in a large German cohort of inflammatory bowel disease (IBD) patients. Methods: Genomic DNA from 2750 individuals (CD: n=832; ulcerative colitis (UC): n=451; controls: n=1478) was analyzed for the NOD2 variants rs2066843, r…

Schlagworte

Zeitschrift für Gastroenterologie