Expression analysis and pharmacological inhibition of embryonic signalling pathways in human cholangiocarcinoma cell lines

Introduction and Aim: Due to the poor prognosis and limited therapeutic approaches the search for new treatment options represents an important task for cholangiocarcinoma (CC). Embryonic signalling pathways have been implicated in oncogenesis of a variety of human tumours. The aim of this study was to investigate the expression of pathway components and correlation with the cellular sensitivity towards selective pathway inhibition in human cholangiocarcinoma cell lines. Methods: In eight human CC cell lines (CCLP-1, CCSW-1, Egi-1, MzChA-1, MzChA-2, SkChA-1, TFK-1 and GBC) obtained from differently graded CCs (G…