CareLit Fachartikel
Identifying genetic modifiers of the TGF-β response in mouse hepatocytes: potential candidate genes for fibrosis susceptibility
R Müllenbach, RA Hall, S Dooley, F Lammert · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
855765
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Jahr
2009
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Zusammenfassung
Aims: TGF-beta is the central cytokine in liver fibrogenesis, and hepatocytes might play an important role through recruitment and activation of Kupffer cells, HSCs and lymphocytes (Dooley et al. 2008). To assess the role of genetic variation in fibrosis susceptibility, we will delineate differences in hepatocellular damage in response to TGF-beta signalling in the BXD genetic reference population (GRP). Differences in damage susceptibility and gene expression will be measured in C57BL/6J, DBA/2J and their recombinant inbred (RI) offspring. Quantification of cellular damage or expression levels in the GRP allows…
Schlagworte
TGF-beta
cell damage
fibrosis
gene expression
hepatocytes
mouse genetics
Zeitschrift für Gastroenterologie
