CareLit Fachartikel
Influence of DSS induced colitis in a model of experimental NASH
E Gäbele, K Dostert, F Obermeier, J Schoelmerich, C Hellerbrand · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
855767
CareLit-ID
Jahr
2009
Publikation
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Metadaten
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ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Intestinal bacterial overgrowth and increased intestinal permeability are pathophysiological features of non alcoholic steatohepatitis (NASH). Further, bacterial endotoxins have been shown to promote NASH progression. Application of dextran sulphate sodium (DSS) is an established model to induce acute colitis in mice characterized by damage of the intestinal barrier and elevated serum endotoxin levels. The aim of this study was to investigate if application of DSS aggravates experimental NASH. Methods and Results: Male C57bl/6 mice (n=6) were randomly allocated into four experimental groups receiving ether…
Schlagworte
NASH
colitis
fibrogenesis
gut liver axis
inflammation
Zeitschrift für Gastroenterologie
